Author: Анюта

Specialization: 010700/03 Physics of condensed matter
Program: 11 Physics of polymers and liquid crystals
Program director: prof. E.I. Riumtsev
Department of Polymer Physics
Scientific advisor: Dr. M.E. Mikhailova 
Reviewer: Dr. V.О. Ivanova

Hydrodynamical and conformational properties of poly(ethylene glycol) modified by sterically hindered phenols in solutions
A.V. Makaronicheva

Water-soluble conjugates are prepared via the chemical modification of poly(ethylene glycol) (PEG) by antioxidants taken from the family of sterically hindered phenols (SHP). High solubility and prolonged action of preparations, an increased stability of biologically active compounds, and their low toxicity level determine prospects of their practical application. The aim of this study was an investigations of the molecular characteristics of conjugates based on PEG modificated by antioxidant groups. Viscometry and dynamic light scattering methods were used to determine hydrodynamic radius and molecular mass of conjugates. It was established that poly(ethylene glycol) molecules carrying end groups of sterically hindered phenols form micellar aggregates that are absent in the solution of the initial polymers. The effect of the molecular mass of PEG and chemical structure of SHP on the dimensions of molecules and their aggregates were studied. The mean number of molecules involved in such an aggregate is 80. Concentration of conjugate’s aggregates in solutions was less than 3 %.

The list of the publications
1. A.V. Makaronicheva, L.A. Dobrun, M.E. Mikhailova, A.V. Lezov. Molecular properties of poly(ethylene glycol) modified by sterically hindered phenols in solutions// Conference abstracts of III International conference «Modern problems of polymer science». St. Petersburg, 2011, P.50.
2. A.V. Makaronicheva, L.A. Dobrun, O.V. Rakitina, M.E. Mikhailova, O.Yu. Sergeeva. Molecular properties of poly(ethylene glycol) modified by sterically hindered phenols// Conference abstracts of 7th Saint-Petersburg Young Scientists Conference “Modern problems of polymer science”, St. Petersburg, 2011, P.56.
3. A.V. Makaronicheva, L.A. Dobrun. Hydrodynamical and conformational properties poly(ethylene glycol) modified by sterically hindered phenols in solutions// Conference abstracts of International student conference “Science and Progress”, St. Petersburg, 2011, P.232.