Author: 1

Specialization: 510406 Biophysics
Program: 18 Molecular Biophysics
Program manager: A.A. Trusov
department of molecular biophysics
Supervisor: prof. N.A. Kasyanenko
Reviewer: prof S.V. Paston

Studying DNA interaction with novel Pd(II) oxalato comlexes in
vitro.
  Z. V. Reveguk

  Some coordination compounds of Palladium belong to a group of potential anticancer agents whose action is similar to cisplatin and is based on binding to DNA. The investigation of novel Palladium compounds with DNA is carried out in a solution by the methods of Spectrophotometry, Circular Dichroism, Atomic Force Microscopy, Viscometry. It was shown that Palladium interacts with DNA  via the formation of coordination bond to N7 Guanine. DNA shrinkage and condensation at high concentration of Palladium compounds were observed.

The list of the publications:

1.	XV Symposium on intermolecular interactions and molecular conformations, 14-18 June 2010, Petrozavodsk, N. Kasyanenko, Z. Reveguk, E. Morozova , Comparison of the effects of  palladium and platinum coordination compounds on the DNA conformation in solution.
2.	2^nd Russian conference for students and graduate students студентов «Young Pharmacy and potential of future», 18-19 April 2012, Saint-Petersburg, N. Kasyanenko, Z. Reveguk, Comparative analysis of the molecular basis of biological effects of palladium (II) compounds with different structures.
3.	Topical issues of experimental, clinical and preventive medicine 2012, 19 April 2012, N. Kasyanenko, Z. Reveguk, I. Efimenko, O. Shishilov, Testing the biological activity of palladium (II) compounds in model systems.
4.	(Ethylenediamine)palladium(II)chloride versus (ethylenediamine)platinum(II)chloride and cis-DDP in the way they cause changes in DNA in vitro, N. Kasyanenko, Z. Reveguk, E. Morozova, R. Ramazanov, B. Shegolev, Journal of structural chemistry – accepted for publication.